Neuro-immunology of atopic dermatitis

SESSION 2 / New fields in AD: big data mining, AD in sub-Saharan Africa, neuroinflammationMartin STEINHOFF (Doha, QATAR)Dept. of DermatologyDermatology InstituteTranslational Research InstituteHamad Medical CorporationWeill Cornell Medicine-QatarQatar University – Doha, Qatar Weill Cornell Medicine New York Overview Video presentationSlides presentation (short version)Full presentation download as PDFAsk questions to Martin STEINHOFF ➜ Ask questions to the author! Author retain copyright. Presentation (short version) Neuro-Inflammation Hosoi J et al. Nature 1993; Steinhoff M et al. Nat Med 2000; Steinhoff M et al. Physiol Rev 2014; Oetjen J et al. Cell 2017; Meng J et al. JACI 2018 Mechanisms of peripheral and central pruritus in AD Steinhoff M et al., Lancet Neurol 2018, Pain 2019 Neuro-Immune Circuits Critically Contribute to Atopic Dermatitis Pathophysiology Steinhoff M et al. Lancet Neurol 2018, J All Clin Immunol 2012; Campion M et al.: Exp Dermatol 2019; Buhl T et al. Front Immunol 2020 Neuronal Cytokine Receptors Mediate Itch, Neuro-Inflammation and Nerve Sprouting IL-31: Sonkoly E et al. JACI 2013; Cevikbas F et al., JACI 2013, JACI 2017; Feld M et al. JACI 2016; Meng J et al, JACI 2018; Hshimoto S et al. Allergy 2019; Kim H et al. Br J Dermatol 2018IL-4/ -13: Oh M-H et al. J Immunol 2012; Oetjen L et al. Cell 2017; Campion M et al. Exp Dermatol 2019TSLP: Wilson S et al. 2013 CCL2/CCR2; CXCR3: Jiang H et al. Brain Behav Immunol 2019; Walsh C et al. Elife 2019 SUMMARY Neuropeptide BNP Regulates Itch and Neuro-Inflammation in AD Meng J. et al, J All Clin Immunol 2018 Meng J et al. J All Ciin Immunol 2018;Meng J et al. J Invest Dermatol 2019 Neuro-Immune circuits as targets for AD therapy IL-31: Sonkoly E et al. JACI 2013; Cevikbas F et al., JACI 2013, JACI 2017; Feld M et al. JACI 2016; Meng J et al, JACI 2018; Hshimoto S et al. Allergy 2019; Kim H et al. Br J Dermatol 2018IL-4/ -13: Oh M-H et al. J Immunol 2012; Oetjen L et al. Cell 2017; Campion M et al. Exp Dermatol 2019TSLP: Wilson S et al. 2013 CCL2/CCR2; CXCR3: Jiang H et al. Brain Behav Immunol 2019; Walsh C et al. Elife 2019 Acknowledgements Münster (DE), UC San Francisco (USA), Dublin (IR), HMC Weill Cornell Med (QA) Düsseldorf, GermanyLab HomeyBMS, USAStacey DillonUC Davis, USALab CarstensTasuku AkiyamaKyushu, JapanLab FurueMakiko KidoMünster, GermanyThomas LugerUCSF, San FranciscoLab BunnettLab JuliusLab CoughlinLab BasbaumLab EliasTimo BuhlMasaki MoriymaErlangen, GermanyPeter ReehMichael FischerWCU-Q, HMC, QatarUwe GielerKarsten SuhreAnna HalamaSteinhoff LabJoerg BuddenkotteMajid AhlamFareed AhmadShahab KhanAtul KumarRoopesh KrisnankuttiJianghui MengAttila SzollosiImre SzaboLeila SmithMichelle CampionAkihiko IkomaFerda CevikbasCordula KempkesMicha Feld Funding NIH/NIAMS; DFG; SFBs, IZKF; SFI, EU; QF, HMC. ➜ download full version as PDF Ask questions to Martin STEINHOFF: Conflict of interest : Abbvie A,I,SAlgorithm A,SAllergan A,SAlmiral A,I,SAnacor A,SAvon A,I,SBaiersdorf A,SBayer Health A,SBMS A,I,SCelgene A,I,SChugai A,SDucray A,I,SEli-Lilly A,I,SGalderma A,I,SGenentech A,SGSK A,IKiniksa ALeo Pharm A,I,SL’Oreal I,SMaruho A,I,SMenloTX A,I,SMitsubishi A,INovartis A,I,SPfizer A,I,SPierre-Fabre A,I,SQatar Pharm SRegeneron A,I,SSalix ASanofi A,I,SToray A,IVertex A,IZymoGenetics A,I,SA, Advisory board; I, Investigator; S, Speaker