Migayron et al. Front Immunol ➜ DOI: 10.3389/fimmu.2024.1405215 Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe? This is an interesting review which approaches indirectly some of the paradoxical findings observed using targeted therapies in AD.
Silverberg et al JAAD ➜ DOI: 10.1016/j.jaad.2024.05.023 Tapinarof Cream 1% Once Daily: Significant Efficacy in the Treatment of Moderate to Severe Atopic Dermatitis in Adults and Children Down to 2 Years of Age in the Pivotal Phase 3 ADORING Trials. This publication was awaited because of the previous meeting presentations, and now head-to-head comparisons with TCS and TCI are needed. The choice of topicals for AD will need to be reassessed in the efficacy/safety/affordability context.
Adhikary et al EMBO Mol Med ➜ DOI: 10.1038/s44321-024-00085-3 Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases. This paper revisits TSLP which was considered as a potential target among epithelial cytokines leading to TH2 inflammation in the skin and a possible link to asthma. It points to the possible engineering of small molecules to block the interaction of TSLP with its receptor.
Dong et al Environ Res ➜ DOI: 10.1016/j.envres.2024.118523 A machine-learning exploration of the exposome from preconception in early childhood atopic eczema, rhinitis and wheeze development. This is an epidemiological study of the AI era using a machine learning approach to explore the role of the exposome starting already in the preconception phase of a Singaporean birth Cohort. The results are a bit surprising and will probably be debated. They suggest that reducing maternal alcohol consumption during preconception and supporting maternal mental health during pregnancy may prevent atopic eczema.
Hülpüsch et al. JACI ➜ DOI: 10.1016/j.jaci.2024.04.029 Exploring the skin microbiome in atopic dermatitis pathogenesis and disease modification. This is a nice and balanced review in a field which is frequently confusing because of the technical difficulty to study the skin microbiome.
