Fecal microbiota transplantation (FMT): first RCT.➜ DOI: 10.1111/all.16372This Chinese randomized, double-blind, placebo-controlled clinical trial, studied the efficacy and safety assessment of FMT for moderate-to-severe adult patients with AD. All patients received FMT or placebo as capsules sourced for FMT verum from 2 strictly screened healthy donors once a week for 3 weeks, in addition to their [...] Read More
Conjunctival transcriptomic profile predicts dupilumab ocular adverse events➜ DOI: 10.1016/j.jid.2024.08.024DNA microarray analysis was used to compare the transcriptome of AD patients’ conjunctival cells collected before and 4 months after initiating dupilumab treatment. Interestingly, patients developing ocular adverse effects had both before and after treatment a similar transcriptome signature, characterized by the over-expression of several genes involved [...] Read More
Vernal keratoconjunctivitis (VKC) and AD➜ DOI: 10.2147/OPTH.S472826The importance of ophthalmological co-morbidities of AD was recently highlighted because of the large literature on dupilumab and ocular surface disorders, but several other aspects are currently neglected. VKC is a refractory ocular allergic disorder that mainly affects boys, and long-term follow-up has been rarely reported. The Department of Ophthalmology [...] Read More
Release of the 4th Davos declaration on AD and Allergy➜ DOI: 10.1111/all.16247The 2022 Forum is now published with its usual “Declaration” signed by all participants. Besides the mounting burden of AD, attributed to significant environmental and lifestyle changes, the Forum acknowledged the progress in understanding AD and in developing targeted therapies but recognized a gap in [...] Read More
#RAJKAMedal Rajka medal and prize: the winner among 7 excellent applicants from originating from China, Japan, Korea and Madagascar, is Dr Fang WANG, MD, PhD, Professor and Chief Physician at Sun Yat-Sen University, Guangzhou, China. Dr WANG has an outstanding CV and list of publications. She is a dermatologist with a strong background in neuroimmunology applied to […]
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Cell therapy for atopic dermatitis➜ DOI: 10.1016/j.jaci.2024.06.021Mesenchymal stem cells (MSCs) have been found to play a role in regulating immune responses. Allogenic human bone marrow-derived clonal MSCs (hcMSCs) were administered intravenously weekly for 3 weeks in volunteers with moderate to severe atopic dermatitis (AD) by Korean investigators, with improvement of objective scores at 12 weeks, with [...] Read More
Migayron et al. Front Immunol➜ DOI: 10.3389/fimmu.2024.1405215Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?This is an interesting review which approaches indirectly some of the paradoxical findings observed using targeted therapies in AD. Silverberg et al JAAD➜ DOI: 10.1016/j.jaad.2024.05.023Tapinarof Cream 1% Once Daily: Significant Efficacy in the Treatment of Moderate to Severe Atopic Dermatitis [...] Read More
Carmanius et al, JEADV 2024➜ DOI: 10.1111/jdv.20076A cross-sectional study based on the 24-year follow-up from the population-based birth cohort linked with dispensing data from the National Swedish Drug Register confirms that a large proportion of young adults with AD is undertreated or untreated. Kook et al, JEADV 2024➜ DOI: 10.1111/jdv.20053Misdiagnosis of AD or confounding skin diseases in [...] Read More
Federica Casetti, Cristina Has➜ First published: 03 March 2024 - DOI: 10.1111/ddg.15358Dupilumab improves congenital ichthyosis in the context of a filaggrin pathogenic variant. This report from Germany confirms other reports of a response of rare ichthyotic conditions such as Netherton’s syndrome and trichothiodystrophy to targeting IL-4Rα, and that the common FLG mutations may accentuate the inflammatory phenotype [...] Read More
Docampo-Simon et al Int J Dermatol 2024➜ First published: 03 March 2024 - DOI: 10.1111/ijd.17100Spanish investigators delineate based on a small case series psoriasis dermatitis, a common ambiguous phenotype of early forms of both psoriasis and atopic dermatitis in children; this phenotype was already well recognized in infants, but this study adds arguments for a later [...] Read More