SESSION 2 / New fields in AD: big data mining, AD in sub-Saharan Africa, neuroinflammation
Martin STEINHOFF (Doha, QATAR)
Dept. of Dermatology
Dermatology Institute
Translational Research Institute
Hamad Medical Corporation
Weill Cornell Medicine-Qatar
Qatar University – Doha, Qatar
Weill Cornell Medicine New York
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Presentation (short version)
Neuro-Inflammation
Mechanisms of peripheral and central pruritus in AD
Neuro-Immune Circuits Critically Contribute to Atopic Dermatitis Pathophysiology
Neuronal Cytokine Receptors Mediate Itch, Neuro-Inflammation and Nerve Sprouting
- IL-31: Sonkoly E et al. JACI 2013; Cevikbas F et al., JACI 2013, JACI 2017; Feld M et al. JACI 2016; Meng J et al, JACI 2018; Hshimoto S et al. Allergy 2019; Kim H et al. Br J Dermatol 2018
- IL-4/ -13: Oh M-H et al. J Immunol 2012; Oetjen L et al. Cell 2017; Campion M et al. Exp Dermatol 2019
- TSLP: Wilson S et al. 2013 CCL2/CCR2; CXCR3: Jiang H et al. Brain Behav Immunol 2019; Walsh C et al. Elife 2019
SUMMARY
Neuropeptide BNP Regulates Itch and Neuro-Inflammation in AD
Meng J et al. J Invest Dermatol 2019
Neuro-Immune circuits as targets for AD therapy
- IL-31: Sonkoly E et al. JACI 2013; Cevikbas F et al., JACI 2013, JACI 2017; Feld M et al. JACI 2016; Meng J et al, JACI 2018; Hshimoto S et al. Allergy 2019; Kim H et al. Br J Dermatol 2018
- IL-4/ -13: Oh M-H et al. J Immunol 2012; Oetjen L et al. Cell 2017; Campion M et al. Exp Dermatol 2019
- TSLP: Wilson S et al. 2013 CCL2/CCR2; CXCR3: Jiang H et al. Brain Behav Immunol 2019; Walsh C et al. Elife 2019
Acknowledgements
| Düsseldorf, Germany Lab Homey BMS, USA Stacey Dillon UC Davis, USA Lab Carstens Tasuku Akiyama Kyushu, Japan Lab Furue Makiko Kido Münster, Germany Thomas Luger | UCSF, San Francisco Lab Bunnett Lab Julius Lab Coughlin Lab Basbaum Lab Elias Timo Buhl Masaki Moriyma Erlangen, Germany Peter Reeh Michael Fischer WCU-Q, HMC, Qatar Uwe Gieler Karsten Suhre Anna Halama | Steinhoff Lab Joerg Buddenkotte Majid Ahlam Fareed Ahmad Shahab Khan Atul Kumar Roopesh Krisnankutti Jianghui Meng Attila Szollosi Imre Szabo Leila Smith Michelle Campion Akihiko Ikoma Ferda Cevikbas Cordula Kempkes Micha Feld |
Funding
NIH/NIAMS; DFG; SFBs, IZKF; SFI, EU; QF, HMC.
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Conflict of interest :
| Abbvie A,I,S Algorithm A,S Allergan A,S Almiral A,I,S Anacor A,S Avon A,I,S Baiersdorf A,S Bayer Health A,S BMS A,I,S Celgene A,I,S Chugai A,S | Ducray A,I,S Eli-Lilly A,I,S Galderma A,I,S Genentech A,S GSK A,I Kiniksa A Leo Pharm A,I,S L’Oreal I,S Maruho A,I,S MenloTX A,I,S Mitsubishi A,I | Novartis A,I,S Pfizer A,I,S Pierre-Fabre A,I,S Qatar Pharm S Regeneron A,I,S Salix A Sanofi A,I,S Toray A,I Vertex A,I ZymoGenetics A,I,S |