Paolo CUSTURONE
MD
Department of Dermatology, University of Messina, Messina, Italy (Guarneri Fabrizio, MD, PhD)
Erasmus MC University Medical Center, Rotterdam, The Netherlands (DirkJan Hijnen, MD, PhD)
December 2022: update
I would like to express again my gratitude for awarding me the ISAD Society research fellowship. Thanks to this exchange period, besides having the privilege of working with such amazing people at Erasmus MC, I was able to follow patients affected by this burdensome disease treated with JAK inhibitors, with some very interesting results. Given that these molecules are relatively new in the clinical practice and are taken by the patients with good compliance, we were able to assess the efficacy, safety, and side effects, putting on the other arm of the scale the amelioration of the EASI and IGA scores’ differences before and after treatment with abrocitinib. Thanking again the AD team led by Prof. DirkJan Hijnen, I look forward to the publication of data collected during this three-month period.
July 2022
The aim of my project is to study the effectiveness of abrocitinib in daily practice. Abrocitinib is one of the latest JAK inhibitors. As a chronic dermatitis, atopic dermatitis (AD) requires often long term prescriptions for patients that are affected by it and, in severe cases, systemic medications. The monoclonal antibodies have improved effectively the quality of life of several patients worldwide, although presents several downsides like cost, way of administration and resistivity in some severe cases or specific subtypes of AD, such as the portrait dermatitis. The latest JAK inhibitors, to which abrocitinib belongs, have demonstrated efficacy, good safety profile and flexibility in dose adjustment, tailored to each patient.
At Erasmus MC, under the supervision of Prof. DirkJan Hijnen, JAK inhibitors are used for patients affected by severe forms of AD and are building a large registry that could be useful for data extraction and comparison with current and future therapies. I am very glad to carry out this project at the Erasmus MC, with the help of the generous support provided by ISAD Research Fellowship 2022.