#StayInformed: June 2024 PubMed curation

  • Migayron et al. Front Immunol
    ➜ DOI: 10.3389/fimmu.2024.1405215
    Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?
    This is an interesting review which approaches indirectly some of the paradoxical findings observed using targeted therapies in AD.
  • Silverberg et al JAAD
    ➜ DOI: 10.1016/j.jaad.2024.05.023
    Tapinarof Cream 1% Once Daily: Significant Efficacy in the Treatment of Moderate to Severe Atopic Dermatitis in Adults and Children Down to 2 Years of Age in the Pivotal Phase 3 ADORING Trials.
    This publication was awaited because of the previous meeting presentations, and now head-to-head comparisons with TCS and TCI are needed. The choice of topicals for AD will need to be reassessed in the efficacy/safety/affordability context.
  • Adhikary et al EMBO Mol Med
    ➜ DOI: 10.1038/s44321-024-00085-3
    Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases.
    This paper revisits TSLP which was considered as a potential target among epithelial cytokines leading to TH2 inflammation in the skin and a possible link to asthma. It points to the possible engineering of small molecules to block the interaction of TSLP with its receptor.
  • Dong et al Environ Res
    ➜ DOI: 10.1016/j.envres.2024.118523
    A machine-learning exploration of the exposome from preconception in early childhood atopic eczema, rhinitis and wheeze development.
    This is an epidemiological study of the AI era using a machine learning approach to explore the role of the exposome starting already in the preconception phase of a Singaporean birth Cohort. The results are a bit surprising and will probably be debated. They suggest that reducing maternal alcohol consumption during preconception and supporting maternal mental health during pregnancy may prevent atopic eczema.
  • Hülpüsch et al. JACI
    ➜ DOI: 10.1016/j.jaci.2024.04.029
    Exploring the skin microbiome in atopic dermatitis pathogenesis and disease modification.
    This is a nice and balanced review in a field which is frequently confusing because of the technical difficulty to study the skin microbiome.