- Federica Casetti, Cristina Has
➜ First published: 03 March 2024 – DOI: 10.1111/ddg.15358
Dupilumab improves congenital ichthyosis in the context of a filaggrin pathogenic variant. This report from Germany confirms other reports of a response of rare ichthyotic conditions such as Netherton’s syndrome and trichothiodystrophy to targeting IL-4Rα, and that the common FLG mutations may accentuate the inflammatory phenotype of the inherited ichthyoses.
- Riichiro Sugiura, Takashi Hashimoto, Satoshi Okuno, Takahiro Satoh
➜ 11 April 2024 – DOI: 10.1111/1346-8138.17229
Expression of phosphorylated-Janus kinase 1 and IL-4Rα by dermal basophils and epidermal keratinocytes in atopic dermatitis-associated prurigo nodules. This well-researched Japanese case report highlight with conventional histopathology and immunocytochemistry that the target of baricitinib in prurigo nodularis could be phosphorylated JAK1 expressed mainly by basophils and epidermal keratinocytes.
- Sara Saheb Kashaf, Heidi H Kong
➜ DOI: 10.1016/j.jid.2024.01.011
Adding Fuel to the Fire? The Skin Microbiome in Atopic Dermatitis. This is a helpful review in a complex field with a warning on untimely intervention. Skin microbiome studies in AD have shown that disease flares are associated with microbial shifts, particularly Staphylococcus aureus predominance. But AD-associated S. aureus strains differ from those in healthy individuals, and we need first to understand better the complex microbiome – barrier- immune system interactions in AD to propose useful interventions.